Cholesterol homeostasis msigdb
WebBackground: Endometrial cancer (EC) is one of the most common gynecological malignancies in women. Cholesterol metabolism has been confirmed to be closely … Webmsigdbr is a handy R package that contains a huge number of pathways that are derived from the Molecular Signatures Database (MSigDB) v7.5.1. Using msigdbr is probably the easiest and most efficient way to generate all the gene sets that you’re interested in.
Cholesterol homeostasis msigdb
Did you know?
WebDec 12, 2015 · The Molecular Signatures Database (MSigDB) is one of the most widely used and comprehensive databases of gene sets for performing gene set enrichment … WebApr 29, 2024 · This compound inhibited Wnt activity, down-regulated expression of the Wnt/β-catenin signature in gene expression studies, disrupted cholesterol homeostasis, and significantly reduced the...
WebMar 30, 2024 · ovarian cancer; TRAP1; cholesterol homeostasis; platinum resistance 1. Introduction Ovarian cancer (OC) encompasses a heterogenous group of malignancies differentiated by cell/site of origin, pathological grade, risk factors, prognosis, and treatment. WebDec 17, 2024 · In this section, we briefly review three crucial players of the cholesterol biosynthetic pathway, namely, sterol regulatory element-binding protein 2 (SREBP2), which functions as a master...
WebCholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease but also an increasing number of other diseases such as neurodegenerative diseases and cancers. The cellular cholesterol level reflects the dynamic bal … WebJan 4, 2013 · Cholesterol homeostasis: a key to prevent or slow down neurodegeneration. Laura Anchisi 1,2, Sandra Dessì 4, Alessandra Pani 3 and Antonella Mandas 4 *. 1 Child Neuropsychiatry Unit, Azienda …
WebDec 1, 2024 · The cellular cholesterol level reflects the dynamic balance between biosynthesis, uptake, export and esterification — a process in which cholesterol is converted to neutral cholesteryl esters...
WebCholesterol homeostasis is a highly regulated process in human body because of its several functions underlying the biology of cell membranes, the synthesis of all steroid hormones and bile acids and the need of trafficking lipids destined to cell metabolism. In particular, it has been recognized th … seaweed florida beaches 2022WebDec 23, 2015 · The Molecular Signatures Database (MSigDB) is one of the most widely used and comprehensive databases of gene sets for performing gene set enrichment analysis. Since its creation, MSigDB has grown beyond its roots in metabolic disease and cancer to include >10,000 gene sets. These better represen … pulmonary lavage treatmentWebLovastatin is an inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR), an enzyme required for cholesterol biosynthesis. The gene encoding this enzyme was found to be... pulmonary langhren providers chicagoWebOct 1, 2024 · To investigate the molecular mechanism for the activation of cholesterol homeostasis pathway by GSK343, the Ingenuity Pathway Analysis (IPA) was performed using the microarray data sets of HepG2 and PLC5 cells treated with 10 μM GSK343 for 16 h. As shown in Figure 1E, 240 and 91 genes were altered in HepG2 and PLC5 cells, … seaweed florida 2023WebAug 2, 2024 · Normally, the cholesterol homeostasis can be well maintained by a dynamic balance among the intake, biosynthesis, transport, cellular uptake and efflux, and/or esterification. Thus, we will... seaweed florida juneWebJan 7, 2024 · Cholesterol is an indispensable component of the cell membrane and plays vital roles in critical physiological processes. Brain cholesterol accounts for a large portion of total cholesterol in the human body, and its content must be tightly regulated to ensure normal brain function. Disorders of cholesterol metabolism in the brain are linked to … pulmonary lawrenceville gaWebMolecules which can sustain or improve mitochondrial function or increase the activity of the protein complex involved in cholesterol transfer may have utility in resolving the problem … pulmonary lesion