Cryptolepine derivatives
WebFeb 16, 2016 · Cryptolepis / chemistry Drug Synergism Drug Therapy, Combination Indole Alkaloids / pharmacology Indole Alkaloids / therapeutic use Malaria / drug therapy* Male Mice Mice, Inbred ICR Plasmodium berghei / drug effects Plasmodium berghei / physiology Quinolines / pharmacology Quinolines / therapeutic use Rats Rats, Sprague-Dawley WebMar 9, 2024 · Other quindoline derivatives 4di, 4fi, and 4gi could also be synthesized by our method. Unlike the annulation of 2g –HCl–H 2 O with 3-methoxybenzothiophene ( 3a) (see 4ga in Table 3 ), the pre-removal of HCl and H 2 O from 2g –HCl–H 2 O as a commercial source is required here to obtain 4gi in reasonable yield.
Cryptolepine derivatives
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WebJun 9, 2024 · A combinatorial library of 31114 derivatives of cryptolepine was formed and the library was virtually screened by molecular docking to predict the molecular interactions between cryptolepine derivatives and TOP2A taking cryptolepine as standard. The overall screening and docking approach explored all the binding poses of cryptolepine … WebSep 27, 2008 · A series of 5-N-methyl quindoline (cryptolepine) derivatives as telomeric quadruplex ligands was synthesized and evaluated, showing a remarkable cessation in population growth and cellular senescence phenotype and accompanied by a shortening of the telomere length. A series of 5-N-methyl quindoline (cryptolepine) derivatives (2a- x) …
WebInteractions of cryptolepine and neocryptolepine with unusual DNA structures. 2003 • ... derivative Hoechst number of monomeric units, failed because the curvature 33258 (Figure 4) is widely used in chromosome stain- of these extended molecules did not match with the natu- ing34, and also possesses antitumour activity and is an in- ral ... WebJan 13, 2024 · Microwave formylation of carbazole derivatives was investigated and 3-monoaldehydes were obtained in high yield. A potential DNA-binding ligand, 3-[(3-ethyl)-2-vinylbenzothiazolium]-9-N-ethyl carbazole iodide, was synthesized and characterized including spectral properties (UV-Vis absorption and fluorescence spectra). The binding …
WebJan 29, 2024 · Neocryptolepine is an alkaloid isolated from traditional African herbal medicine Cryptolepis sanguinolenta and its broad spectrum of biological activities have been illuminated in past decades. In... Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Web(2024) Y.J. Chen et al. Design, synthesis, and antifungal evaluation of cryptolepine derivatives against phytopathogenic fungi J. Agric. Food Chem. (2024) D. Danzi et al. Effectiveness of essential oil extracted from pompia leaves against Penicillium digitatum J. Sci. Food Agric. (2024) View more references Cited by (0) Recommended articles (4 ...
WebMar 2, 2024 · Abstract Based on the structural characteristics of the cryptolepine alkaloid, a series of new quindoline derivatives bearing various substituents were prepared and evaluated for their fungicidal and antibacterial activities. quotes on greatness by famous peopleWebJun 9, 2024 · this compound to be converted into effective anticancer drug by making its derivatives. Addition of small functional groups to cryptolepine at various positions will … shirts rzaWebA series of quinoline derivatives were designed and synthesized by the structural simplification of cryptolepine and evaluated for their fungicidal activity against six phytopathogenic fungi. Most of these compounds exhibited remarkable activities against Botrytis cinereain vitro. quotes on gratitude and appreciationWebFeb 3, 2024 · Inspired by the widely antiphytopathogenic application of diversified derivatives from natural sources, cryptolepine and its derivatives were subsequently … shirts sale great plainsWebThe strong binding interactions of these derivatives show that they can be used as potent TOP2A inhibitors and act as more effective anticancer agents than cryptolepine itself. … shirts rustWebMay 22, 2024 · Cryptolepine and its quindoline derivatives have been identified as G4 ligands and have been shown to have significant effects against several types of cancer cells [ 27 − 30 ]. However, only two cryptolepine Zn (II) metal complexes have been reported to have anticancer effects thus far (Fig. S1) [ 29, 30 ]. shirts r us 441WebSep 19, 2012 · Abstract In order to improve the selectivity of 5-N-methyl quindoline (cryptolepine) derivatives as telomeric quadruplex binding ligands versus duplex DNA, a series of peptidyl-benzofuroquinoline (P-BFQ) conjugates (2a-2n) … shirts ruffle