Gambogic acid icd
WebJul 3, 2024 · Gambogic acid, a common traditional Chinese medicine and widely distributed throughout South China, Vietnam, Cambodia, and Thailand. It is prenylated xanthone which is the significant bioactive... WebJul 12, 2024 · Here we report that gambogic acid suppresses the pentose phosphate pathway (PPP) by covalently inhibiting the 6-phosphogluconate dehydrogenase (6PGD) …
Gambogic acid icd
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WebGambogic acid is an apoptosis inducer in several tumor cell lines including T47D cells. Activates caspases (EC 50 values are 0.78 - 1.64 μM) and competitively inhibits antiapoptotic Bcl-2 family proteins (IC 50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). WebApr 4, 2012 · Related toxicological studies demonstrated that the LD 50 of gambogic acid is 45–96 mg/kg in experiments using mice. Chronic toxicity studies in these animals indicated that gambogic acid did not affect their cardiovascular and respiratory functions [98] but, at high doses, it induced toxic effects in the liver and kidneys [99].
WebJan 10, 2024 · Gambogic acid is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic acid inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM. Properties Articles 29 Spectrum Names Gambogic Acid Biological Activity Chemical & Physical Properties MSDS WebYang J et al., 2012, Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain., J Nat Prod ChemblDrugs: …
WebDec 5, 2024 · Extracted from gamboge resin, gambogic acid (GBA) is a natural product that displays a complex caged xanthone structure and exhibits promising … WebThe IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively. All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use. Gambogic Acid, CAS 2752-65-0. Please contact us for prices and availability for the specification of ...
WebTrade name:Gambogic Acid (Contd. from page 2) 55.1.8.1 3 Composition/information on ingredients · Chemical characterization: Substances · CAS No. Description 2752-65-0 …
WebGambogic acid (GA) is a compound isolated from the brownish orange gamboge resin of the Garcinia hanburyi tree (93) and undertakes anti-proliferative, anti-apoptotic, anti-tumorigenic ... deck of cards creatorSome pharmacological research on gambogic acid has been conducted in vitro and in laboratory animals, but there are no proven clinical effects in humans. In studies conducted with mice and transplanted tumors (from human lung carcinoma SPC-A1 cells), tumor growth remained suppressed for up to 21 days during treatment with gambogic acid. The ratio of relative tumor volume (RTV) for the treated group of mice to the control group indic… february half term 2023 shropshireWebDec 22, 2024 · Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyitree, is a natural active ingredient with various biological activities, such as anti … deck of cards clubWebGambogic acid (Fig. 15) is a xanthonoid isolated from the exudate of Garcinia hanburyi Hook f. (Clusiaceae) and has been used for centuries to treat infections and tumors (Ren et al., 2011).In recent decades, interest in gambogic acid as a potential anticancer agent has increased because it demonstrates antitumor, antiangiogenic, and antimetastatic … deck of cards club meaningWebSep 1, 2024 · The molar mass of neogambogic acid is 646.77 g·mol−1 and its molecular formula is C38H46O9. It appears as yellow crystalline, since it’s in large amount in the original ingredients, the extraction process is simple and low-cost, showing significant value of research and develop- ment [3]. deck of cards club imageWeb4.2.5 Gambogic Acid, a Disruptor of Hsp90–Cdc37 Interaction Gambogic acid (Fig. 15) is a xanthonoid isolated from the exudate of Garcinia hanburyi Hook f. (Clusiaceae) and … deck of cards cloverWebNeogambogic acid C38H46O9 CID 6438568 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... february half term 2023 sutton