Metabolism of vinyl chloride
Web14 mrt. 2016 · Vinyl chloride (VC) is a carcinogen generated in groundwater by reductive dechlorination of chloroethenes. Under aerobic conditions, etheneotrophs oxidize ethene … WebA superoxide (O2) generating system comprised of phenazine methosulfate and NADH also converts 14 C-vinyl chloride to metabolites which irreversibly bind to …
Metabolism of vinyl chloride
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Web10 okt. 2008 · Vinyl chloride requires metabolic activation for carcinogenicity and mutagenicity, and toxicokinetics are a key to interpret the dose response. Practically the … WebStudies on the Metabolism of Vinyl Chloride by H. Antweiler* Vinyl chloride tVCM) is not carcinogenic by itself. it is bioactivated to the highly reactive alkylating oxirane …
WebEnvironmental Health Perspectives Vol. 17, pp. 217-219, 1976 Studiesonthe Metabolism of Vinyl Chloride byH. Antweiler* Vinyl chloride (VCM) is not carcinogenic by itself. it is … Webmetabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. Hepatic micro …
WebThe epoxidation of vinyl chloride to chloroethylene oxide is the key step in the metabolism of vinyl chloride; it is readily saturable; nevertheless covalent binding to DNA occurs at … WebElucidation of the role of vinyl chloride metabolites in the various reaction sequences which comprise the metabolic pathway, including the interaction of reactive metabolities with …
Web9 feb. 2024 · It is well known that the risk for developing chronic liver injury is influenced by multiple factors, such as genetics, comorbidities, and/or lifestyle choices, such as diet. 12 Obesity is a major problem in the United States, with over 68% of the population obese (BMI ≥30). 11, 13 Nonalcoholic fatty liver disease (NAFLD) is the major hepatic manifestation …
Webexperiments with vinyl chloride. A feasible metabolic pathway for thiodiglycollic acid from chloroacetic acid and involving cysteine desulflly-drase is unacceptable. Experiments with unlabeled vinyl chloride in rats in which the cysteinesystine pools had been labeled adequately with 14C gave [l4C]thiodiglycollic acid, showing that a part of the magnite turboWebR.J. Preston, J.A. Ross, in Comprehensive Toxicology, 2010 1.16.3.5 Halogenated Hydrocarbons. Occupational exposure to vinyl chloride is associated with a high … cp srl di cubi luca \\u0026 perina giancarloWebVinyl chloride (CAS Reg. No. 75-01-4), also known as chloroethene, is a halogenated aliphatic hydrocarbon with the empirical formula of C 2 H 3 Cl and a molecular weight of … cps retrialWebChloroacetaldehyde is a metabolite in the degradation of 1,2-dichloroethane, which initially converts to chloroethanol. This metabolic pathway is topical because 1,2-dichloroethane is produced on a large as a precursor to vinyl chloride. [8] Safety [ edit] Chloroacetaldehyde is corrosive to mucous membranes. magnit global - sign in okta.comWeb1 jun. 2004 · It is demonstrated that metabolic vinyl chloride (VC) degradation by an enrichment culture originating from groundwater was not affected by an equimolar concentration (50 μM) of cis-1,2-dichloroethene (cDCE) or cis- 1,1-DCE (tDCE), and only cDCE and tDCE were cometabolically degraded in small amounts. 4 cps rio nogalesWeb1 mrt. 2024 · Vinyl chloride is primarily metabolized to chloroethylene oxide by hepatic CYP2E1. The active metabolite undergoes rearrangement to chloroacetaldehyde or is … cps rio grande cityWeb8 mrt. 2016 · Vinyl chloride (VC) is an organochlorine used to create the polymer, polyvinyl chloride. VC is ranked as the 4th most important toxic chemical on the Hazardous … cpssaig ed