Webb8 apr. 2016 · TGF-β1 induces cell cycle arrest at the G1 phase by suppressing cyclin-dependent kinase (Cdk) activity through the induction of Cdk inhibitors, including p15INK4B, p21WAF1 or p27KIP1 [3], [4], [5]. Smad3 plays an important role in transcriptional regulation of cell cycle regulators in response to TGF-β1. WebbPhospho-Smad3 (S213) Polyclonal Antibody detects endogenous levels of Smad3 protein only when phosphorylated at S213. Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Source: Polyclonal, Rabbit,IgG Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000.
SIS3 is a Potent and Selective Inhibitor of Smad3 Phosphorylation
Webb7 apr. 2024 · In addition, SARS-CoV-2 N protein may trigger multiple cell death pathways to induce AKI as reported here via the Smad3-RIPK3/MLKL necroptosis pathway and the other study under ischemic conditions ... WebbCDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions ... (5ng/ml, 24h) + Lamda phosphatase (LP) cells. Smad3 (phospho S423 + S425) was labelled with purified ab52903 at a dilution of 1/100 dilution, while Smad3 was labelled with ab207447 at a dilution ... sma healthcare applicant stack
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WebbSmad3-induced embryonic dorsalization by physically interacting with and preventing Smad3 from binding to one of its cofactors, p300 (4). In mammalian cells, mRNA decay begins with deadenylation. Regulation of the critical deadenylation step occurs at the RNA processing bodies (P-bodies), a site where poly (A)-shortened mRNA gets degraded. Webb23 nov. 2024 · SARS-CoV-2 N Protein Induces Acute Kidney Injury via Smad3-Dependent G1 Cell Cycle Arrest Mechanism. Wenbiao Wang Departments of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China. Search articles by … solhestar horse rental